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Two-tiered biological containment strategy for Lactococcus lactis-based vaccine or immunotherapy vectors
The concept of biological containment was developed as a strategy to prevent environmental dissemination of engineered live vaccine or drug delivery vehicles. A mutation in the gene encoding thymidylate synthase (thyA), a key enzyme in the pyrimidine biosynthetic pathway, has previously been shown t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4185911/ https://ncbi.nlm.nih.gov/pubmed/24196273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.26954 |
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