Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

Hexadecyloxypropyl esters of acyclic nucleoside phosphonates containing guanine (G) or hypoxanthine (Hx) and a (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] [(S)-HPMP] or 2-(2-phosphonoethoxy)ethyl (PEE) acyclic moiety have been prepared. The activity of the prodrugs was evaluated in vitro against diff...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Tichý, Tomáš, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Dračínský, Martin, Krečmerová, Marcela
Formato: Artigo
Idioma:Inglês
Publicado em: Published by Elsevier Masson SAS 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115494/
https://ncbi.nlm.nih.gov/pubmed/22858222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.07.027
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