Polyprotein cleavage mechanism of SARS CoV M(pro) and chemical modification of the octapeptide

The cleavage mechanism of severe acute respiratory syndrome (SARS) coronavirus main proteinase (M(pro) or 3CL(pro)) for the octapeptide AVLQSGFR is studied using molecular mechanics (MM) and quantum mechanics (QM). The catalytic dyad His-41 and Cys-145 in the active pocket between domain I and II se...

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Publicado en:Peptides
Autores principales: Du, Qi-Shi, Wang, Shu-Qing, Zhu, Yu, Wei, Dong-Qing, Guo, Hong, Sirois, Suzanne, Chou, Kuo-Chen
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Inc. 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115412/
https://ncbi.nlm.nih.gov/pubmed/15501516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2004.06.018
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