Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

Recently we identified cycloguanil-like dihydrotriazine derivatives, which provided host-factor directed antiviral activity against influenza viruses and respiratory syncytial virus (RSV), by targeting the human dihydrofolate reductase (hDHFR) enzyme. In this context we deemed interesting to further...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Francesconi, Valeria, Giovannini, Luca, Santucci, Matteo, Cichero, Elena, Costi, Maria Paola, Naesens, Lieve, Giordanetto, Fabrizio, Tonelli, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115377/
https://ncbi.nlm.nih.gov/pubmed/29886325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.05.059
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