Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning

Objectives: Current therapeutic options for organophosphorus (OP) insecticide self-poisoning including atropine and oximes are inadequate and case fatality may exceed 20%. An OP hydrolase enzyme, OpdA, has been used for environmental cleansing of OP insecticides and prevented death in rat and non-hu...

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Detalhes bibliográficos
Publicado no:Clin Toxicol (Phila)
Main Authors: Eddleston, Michael, Clutton, R. Eddie, Taylor, Matthew, Thompson, Adrian, Worek, Franz, John, Harald, Thiermann, Horst, Scott, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114914/
https://ncbi.nlm.nih.gov/pubmed/31452424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15563650.2019.1655149
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