Use of OpdA, an Organophosphorus (OP) Hydrolase, Prevents Lethality in an African Green Monkey Model of Acute OP Poisoning

Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that are responsible for tremendous morbidity and mortality worldwide, killing approximately 300,000 people annually. Enzymatic hydrolysis of OPs is a potential therapy for acute poisoning. OpdA, an OP hyd...

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Veröffentlicht in:Toxicology
Hauptverfasser: Jackson, Colin J, Carville, Angela, Ward, Jeanine, Mansfield, Keith, Ollis, David L., Khurana, Tejvir, Bird, Steven B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419748/
https://ncbi.nlm.nih.gov/pubmed/24447378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2014.01.003
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