Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

Coronaviruses (CoV) and picornaviruses are plus-strand RNA viruses that use 5′ cap-dependent and cap-independent strategies, respectively, for viral mRNA translation initiation. Here, we analyzed the effects of the plant compound silvestrol, a specific inhibitor of the DEAD-box RNA helicase eIF4A, o...

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Publicado no:Antiviral Res
Main Authors: Müller, Christin, Schulte, Falk W., Lange-Grünweller, Kerstin, Obermann, Wiebke, Madhugiri, Ramakanth, Pleschka, Stephan, Ziebuhr, John, Hartmann, Roland K., Grünweller, Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113723/
https://ncbi.nlm.nih.gov/pubmed/29258862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.12.010
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