Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol

Rocaglates, a class of natural compounds isolated from plants of the genus Aglaia, are potent inhibitors of translation initiation. They are proposed to form stacking interactions with polypurine sequences in the 5′-untranslated region (UTR) of selected mRNAs, thereby clamping the RNA substrate onto...

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Publicado no:Antiviral Res
Main Authors: Müller, Christin, Obermann, Wiebke, Schulte, Falk W., Lange-Grünweller, Kerstin, Oestereich, Lisa, Elgner, Fabian, Glitscher, Mirco, Hildt, Eberhard, Singh, Kamini, Wendel, Hans-Guido, Hartmann, Roland K., Ziebuhr, John, Grünweller, Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114339/
https://ncbi.nlm.nih.gov/pubmed/31931103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104706
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