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Effective CRISPRa-mediated control of gene expression in bacteria must overcome strict target site requirements
In bacterial systems, CRISPR-Cas transcriptional activation (CRISPRa) has the potential to dramatically expand our ability to regulate gene expression, but we lack predictive rules for designing effective gRNA target sites. Here, we identify multiple features of bacterial promoters that impose strin...
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| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7113249/ https://ncbi.nlm.nih.gov/pubmed/32238808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15454-y |
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