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Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors

BACKGROUND: Neoadjuvant tyrosine kinase inhibitor (TKI) therapy increases the chance of organ-preserving, radical resection in selected patients with gastrointestinal stromal tumors (GISTs). We aimed to evaluate systematic, immediate DNA sequencing of KIT and PDGFRA in pretreatment GIST tissue to gu...

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Bibliografiske detaljer
Udgivet i:Mol Diagn Ther
Main Authors: Hedenström, Per, Andersson, Carola, Sjövall, Henrik, Enlund, Fredrik, Nilsson, Ola, Nilsson, Bengt, Sadik, Riadh
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113213/
https://ncbi.nlm.nih.gov/pubmed/32124386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40291-020-00451-0
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