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Development of robust in vitro RNA-dependent RNA polymerase assay as a possible platform for antiviral drug testing against dengue

NS5 is the largest and most conserved protein among the four dengue virus (DENV) serotypes. It has been the target of interest for antiviral drug development due to its major role in replication. NS5 consists of two domains, the N-terminal methyltransferase domain and C-terminal catalytic RNA-depend...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Enzyme Microb Technol
Autori principali: Amraiz, Deeba, Zaidi, Najam-us-Sahar Sadaf, Fatima, Munazza
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Inc. 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112394/
https://ncbi.nlm.nih.gov/pubmed/27542741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.enzmictec.2016.06.010
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