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Development of robust in vitro RNA-dependent RNA polymerase assay as a possible platform for antiviral drug testing against dengue

NS5 is the largest and most conserved protein among the four dengue virus (DENV) serotypes. It has been the target of interest for antiviral drug development due to its major role in replication. NS5 consists of two domains, the N-terminal methyltransferase domain and C-terminal catalytic RNA-depend...

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Bibliografski detalji
Izdano u:Enzyme Microb Technol
Glavni autori: Amraiz, Deeba, Zaidi, Najam-us-Sahar Sadaf, Fatima, Munazza
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Inc. 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112394/
https://ncbi.nlm.nih.gov/pubmed/27542741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.enzmictec.2016.06.010
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