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An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring opening afford the acid 2a, which is coupled w...
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| Publicat a: | Tetrahedron Lett |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Ltd.
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7111835/ https://ncbi.nlm.nih.gov/pubmed/32287436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2004.08.179 |
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