A carregar...

An efficient and tunable route to AG7088, a rhinovirus protease inhibitor

Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring opening afford the acid 2a, which is coupled w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Ma, Dawei, Xie, Weiqing, Zou, Bin, Lei, Qiong, Pei, Duanqing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111835/
https://ncbi.nlm.nih.gov/pubmed/32287436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2004.08.179
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!