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Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells
The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and th...
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| Udgivet i: | Phytochemistry |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Ltd.
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7111684/ https://ncbi.nlm.nih.gov/pubmed/19464034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phytochem.2009.04.012 |
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