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Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest

The cis-stilbene, combretastatin A4 (CA4), is a potent microtubule targeting and vascular damaging agent. Despite promising results at the pre-clinical level and extensive clinical evaluation, CA4 has yet to be approved for therapeutic use. One impediment to the development of CA4 is an inherent con...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tarade, Daniel, Ma, Dennis, Pignanelli, Christopher, Mansour, Fadi, Simard, Daniel, van den Berg, Sean, Gauld, James, McNulty, James, Pandey, Siyaram
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333808/
https://ncbi.nlm.nih.gov/pubmed/28253265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171806
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