CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

BACKGROUND: Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the context of cu...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Liu, S. John, Malatesta, Martina, Lien, Brian V., Saha, Parna, Thombare, Shivani S., Hong, Sung Jun, Pedraza, Leslie, Koontz, Mark, Seo, Kyounghee, Horlbeck, Max A., He, Daniel, Birk, Harjus S., Jain, Miten, Olsen, Hugh E., Akeson, Mark, Weissman, Jonathan S., Monje, Michelle, Gupta, Nalin, Raleigh, David R., Ullian, Erik M., Lim, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110660/
https://ncbi.nlm.nih.gov/pubmed/32234056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01995-4
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