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Saturation Mutagenesis reveals that GLU54 of Norovirus 3C-like Protease is not Essential for the Proteolytic Activity

The norovirus 3C-like protease is a member of the chymotrypsin-like serine protease superfamily. Previous characterization of its crystal structure has implicated the Glu54–His30–Cys139 triad in the catalysis. In the present study, the Glu54 residue of the protease was subjected to site-saturation m...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Biochem
Asıl Yazarlar: Someya, Yuichi, Takeda, Naokazu, Wakita, Takaji
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109903/
https://ncbi.nlm.nih.gov/pubmed/18838436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvn130
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