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A Norovirus Protease Structure Provides Insights into Active and Substrate Binding Site Integrity
Norovirus 3C-like proteases are crucial to proteolytic processing of norovirus polyproteins. We determined the crystal structure of the 3C-like protease from Chiba virus, a norovirus, at 2.8-Å resolution. An active site including Cys139 and His30 is present, as is a hydrogen bond network that stabil...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1262588/ https://ncbi.nlm.nih.gov/pubmed/16227288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13685-13693.2005 |
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