Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells

Leukemia stem cells contribute to drug-resistance and relapse in chronic myeloid leukemia (CML) and BCR-ABL1 inhibitor monotherapy fails to eliminate these cells, thereby necessitating alternate therapeutic strategies for patients CML. The peroxisome proliferator-activated receptor-γ (PPARγ) agonist...

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Publicado en:Haematologica
Autores principales: Kumar, Harish, Chattopadhyay, Sourav, Das, Nabanita, Shree, Sonal, Patel, Dinesh, Mohapatra, Jogeswar, Gurjar, Anagha, Kushwaha, Sapana, Singh, Abhishek Kumar, Dubey, Shikha, Lata, Kiran, Kushwaha, Rajesh, Mohammed, Riyazuddin, Dastidar, Krishnarup Ghosh, Yadav, Namrata, Vishwakarma, Achchhe Lal, Gayen, Jiaur Rahaman, Bandyopadhyay, Sanghamitra, Chatterjee, Abhijit, Jain, Mukul Rameshchandra, Tripathi, Anil Kumar, Trivedi, Arun Kumar, Chattopadhyay, Naibedya, Ramachandran, Ravishankar, Sanyal, Sabyasachi
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109729/
https://ncbi.nlm.nih.gov/pubmed/31371410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.194910
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