Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells

Leukemia stem cells contribute to drug-resistance and relapse in chronic myeloid leukemia (CML) and BCR-ABL1 inhibitor monotherapy fails to eliminate these cells, thereby necessitating alternate therapeutic strategies for patients CML. The peroxisome proliferator-activated receptor-γ (PPARγ) agonist...

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Vydáno v:Haematologica
Hlavní autoři: Kumar, Harish, Chattopadhyay, Sourav, Das, Nabanita, Shree, Sonal, Patel, Dinesh, Mohapatra, Jogeswar, Gurjar, Anagha, Kushwaha, Sapana, Singh, Abhishek Kumar, Dubey, Shikha, Lata, Kiran, Kushwaha, Rajesh, Mohammed, Riyazuddin, Dastidar, Krishnarup Ghosh, Yadav, Namrata, Vishwakarma, Achchhe Lal, Gayen, Jiaur Rahaman, Bandyopadhyay, Sanghamitra, Chatterjee, Abhijit, Jain, Mukul Rameshchandra, Tripathi, Anil Kumar, Trivedi, Arun Kumar, Chattopadhyay, Naibedya, Ramachandran, Ravishankar, Sanyal, Sabyasachi
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109729/
https://ncbi.nlm.nih.gov/pubmed/31371410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.194910
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