The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation

Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα (GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage (desialylation) triggers clearance of platelets. Neuraminidases (NEU) are responsible for desialylation and so far, NEU1-4 have...

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Bibliographic Details
Published in:Haematologica
Main Authors: van der Wal, Dianne E., Davis, April M., Mach, Melanie, Marks, Denese C.
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109719/
https://ncbi.nlm.nih.gov/pubmed/31273092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.215830
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