Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice

BACKGROUND: Ubiquitin-like modifier activating enzyme 1 (UBA1) is the first and major E1 activating enzyme in ubiquitin activation, the initial step of the ubiquitin-proteasome system. Defects in the expression or activity of UBA1 correlate with several neurodegenerative and cardiovascular disorders...

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Vydáno v:J Immunol Res
Hlavní autoři: Liao, Jiawei, Yang, Xiaolei, Lin, Qiuyue, Liu, Shuang, Xie, Yunpeng, Xia, Yunlong, Li, Hui-Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109586/
https://ncbi.nlm.nih.gov/pubmed/32258175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/7812709
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