Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects

Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored in vivo, AlloP may confer protection against the neurological dysfunction associated with human immunodeficiency virus type 1 (HIV-1). The HIV-1 regulatory protein, trans-act...

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Detalhes bibliográficos
Publicado no:Neurobiol Stress
Main Authors: Paris, Jason J., Liere, Philippe, Kim, Sarah, Mahdi, Fakhri, Buchanan, Meagan E., Nass, Sara R., Qrareya, Alaa N., Salahuddin, Mohammed F., Pianos, Antoine, Fernandez, Neïké, Shariat-Madar, Zia, Knapp, Pamela E., Schumacher, Michael, Hauser, Kurt F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Articles from the Special Issue on Allopregnanolone role in the neurobiology of stress and mood disorders; Edited by Graziano Pinna
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109513/
https://ncbi.nlm.nih.gov/pubmed/32258256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2020.100211
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