C3G contributes to platelet activation and aggregation by regulating major signaling pathways

C3G is a GEF (guanine nucleotide exchange factor) for Rap GTPases, among which the isoform Rap1b is an essential protein in platelet biology. Using transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat, we have unveiled a new function of C3G in regulating the hemosta...

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Publié dans:Signal Transduct Target Ther
Auteurs principaux: Gutiérrez-Herrero, Sara, Fernández-Infante, Cristina, Hernández-Cano, Luis, Ortiz-Rivero, Sara, Guijas, Carlos, Martín-Granado, Víctor, González-Porras, José Ramón, Balsinde, Jesús, Porras, Almudena, Guerrero, Carmen
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109025/
https://ncbi.nlm.nih.gov/pubmed/32296045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0119-9
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