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C3G contributes to platelet activation and aggregation by regulating major signaling pathways
C3G is a GEF (guanine nucleotide exchange factor) for Rap GTPases, among which the isoform Rap1b is an essential protein in platelet biology. Using transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat, we have unveiled a new function of C3G in regulating the hemosta...
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| Publicado no: | Signal Transduct Target Ther |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7109025/ https://ncbi.nlm.nih.gov/pubmed/32296045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0119-9 |
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