Graft-versus-host disease reduces lymph node display of tissue-restricted self-antigens and promotes autoimmunity

Acute graft-versus-host disease (GVHD) is initially triggered by alloreactive T cells, which damage peripheral tissues and lymphoid organs. Subsequent transition to chronic GVHD involves the emergence of autoimmunity, although the underlying mechanisms driving this process are unclear. Here, we test...

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Pubblicato in:J Clin Invest
Autori principali: Dertschnig, Simone, Evans, Pamela, Santos e Sousa, Pedro, Manzo, Teresa, Ferrer, Ivana R., Stauss, Hans J., Bennett, Clare L., Chakraverty, Ronjon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108931/
https://ncbi.nlm.nih.gov/pubmed/31917684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133102
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