A Novel Immunogen Selectively Eliciting CD8(+) T Cells but Not CD4(+) T Cells Targeting Immunodeficiency Virus Antigens

Optimization of immunogen is crucial for induction of effective T-cell responses in the development of a human immunodeficiency virus (HIV) vaccine. Conventional T-cell-based vaccines have been designed to induce virus-specific CD4(+) T as well as CD8(+) T cells. However, it has been indicated that...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Ishii, Hiroshi, Terahara, Kazutaka, Nomura, Takushi, Takeda, Akiko, Okazaki, Midori, Yamamoto, Hiroyuki, Tokusumi, Tsuyoshi, Shu, Tsugumine, Matano, Tetsuro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108830/
https://ncbi.nlm.nih.gov/pubmed/32024773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01876-19
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