Polymorphisms in Human Cytomegalovirus Glycoprotein O (gO) Exert Epistatic Influences on Cell-Free and Cell-to-Cell Spread and Antibody Neutralization on gH Epitopes

Human cytomegalovirus (HCMV) glycoproteins H and L (gH/gL) can be bound by either gO or the UL128 to UL131 proteins (referred to here as UL128-131) to form complexes that facilitate entry and spread, and the complexes formed are important targets of neutralizing antibodies. Strains of HCMV vary cons...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Day, Le Zhang, Stegmann, Cora, Schultz, Eric P., Lanchy, Jean-Marc, Yu, Qin, Ryckman, Brent J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Genetic Diversity and Evolution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108825/
https://ncbi.nlm.nih.gov/pubmed/31996433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02051-19
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