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Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism

Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by gO or by the set of proteins UL128, UL130, and UL131, forming gH/gL/gO and gH/gL/UL128-131. The mechanisms by which these...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhou, Momei, Lanchy, Jean-Marc, Ryckman, Brent J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524070/
https://ncbi.nlm.nih.gov/pubmed/26085146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01325-15
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