Soluble Human Cytomegalovirus gH/gL/pUL128–131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes

Congenital infection of human cytomegalovirus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine against HCMV is of high priority for public health. The gH/gL/pUL128–131 pentameric complex mediates HCMV entry into endothelial and epithelial cel...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Loughney, John W., Rustandi, Richard R., Wang, Dai, Troutman, Matthew C., Dick, Lawrence W., Li, Guanghua, Liu, Zhong, Li, Fengsheng, Freed, Daniel C., Price, Colleen E., Hoang, Van M., Culp, Timothy D., DePhillips, Pete A., Fu, Tong-Ming, Ha, Sha
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481204/
https://ncbi.nlm.nih.gov/pubmed/25947373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652230
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