Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001

PURPOSE: Radiation dose to the neuroregenerative zone of the hippocampus has been found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain radiotherapy (WBRT) is hypothesized to preserve cognition. METHODS: This phase III tr...

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Pubblicato in:J Clin Oncol
Autori principali: Brown, Paul D., Gondi, Vinai, Pugh, Stephanie, Tome, Wolfgang A., Wefel, Jeffrey S., Armstrong, Terri S., Bovi, Joseph A., Robinson, Cliff, Konski, Andre, Khuntia, Deepak, Grosshans, David, Benzinger, Tammie L. S., Bruner, Deborah, Gilbert, Mark R., Roberge, David, Kundapur, Vijayananda, Devisetty, Kiran, Shah, Sunjay, Usuki, Kenneth, Anderson, Bethany Marie, Stea, Baldassarre, Yoon, Harold, Li, Jing, Laack, Nadia N., Kruser, Tim J., Chmura, Steven J., Shi, Wenyin, Deshmukh, Snehal, Mehta, Minesh P., Kachnic, Lisa A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106984/
https://ncbi.nlm.nih.gov/pubmed/32058845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.02767
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