Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001

PURPOSE: Radiation dose to the neuroregenerative zone of the hippocampus has been found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain radiotherapy (WBRT) is hypothesized to preserve cognition. METHODS: This phase III tr...

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Udgivet i:J Clin Oncol
Main Authors: Brown, Paul D., Gondi, Vinai, Pugh, Stephanie, Tome, Wolfgang A., Wefel, Jeffrey S., Armstrong, Terri S., Bovi, Joseph A., Robinson, Cliff, Konski, Andre, Khuntia, Deepak, Grosshans, David, Benzinger, Tammie L. S., Bruner, Deborah, Gilbert, Mark R., Roberge, David, Kundapur, Vijayananda, Devisetty, Kiran, Shah, Sunjay, Usuki, Kenneth, Anderson, Bethany Marie, Stea, Baldassarre, Yoon, Harold, Li, Jing, Laack, Nadia N., Kruser, Tim J., Chmura, Steven J., Shi, Wenyin, Deshmukh, Snehal, Mehta, Minesh P., Kachnic, Lisa A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106984/
https://ncbi.nlm.nih.gov/pubmed/32058845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.02767
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