General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing

Hedgehog (Hh) autoprocessing converts Hh precursor protein to cholesterylated Hh ligand for downstream signaling. A conserved active-site aspartate residue, D46, plays a key catalytic role in Hh autoprocessing by serving as a general base to activate substrate cholesterol. Here we report that a char...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Zhao, Jing, Ciulla, Daniel A., Xie, Jian, Wagner, Andrew G., Castillo, Drew A., Zwarycz, Allison S., Lin, Zhongqian, Beadle, Seth, Giner, José-Luis, Li, Zhong, Li, Hongmin, Banavali, Nilesh, Callahan, Brian P., Wang, Chunyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106946/
https://ncbi.nlm.nih.gov/pubmed/31682419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08914
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