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Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics
Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. This conformational restriction results in unprecedented hybridization affinity towards complementary single stranded RNA a...
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| Udgivet i: | Drug Discov Today Technol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Ltd.
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7105916/ https://ncbi.nlm.nih.gov/pubmed/24981949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2005.08.012 |
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