Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

Estrogen contributes to females' strong antibody response to microbial vaccines and proneness to autoimmunity, particularly antibody-mediated systemic autoimmunity, in females. We have hypothesized that this is due to estrogen-mediated potentiation of class switch DNA recombination (CSR) and so...

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Опубликовано в: :Front Immunol
Главные авторы: Casali, Paolo, Shen, Tian, Xu, Yijiang, Qiu, Zhifang, Chupp, Daniel P., Im, John, Xu, Zhenming, Zan, Hong
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105609/
https://ncbi.nlm.nih.gov/pubmed/32265934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00491
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