Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2–mediated activation of forkhead box O1

Recent clinical investigations indicate that anthracycline-based chemotherapies induce early decline in heart mass in cancer patients. Heart mass decline may be caused by a decrease in cardiac cell number because of increased cell death or by a reduction in cell size because of atrophy. We previousl...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Xia, Peng, Chen, Jingrui, Liu, Yuening, Fletcher, Maya, Jensen, Brian C., Cheng, Zhaokang
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105316/
https://ncbi.nlm.nih.gov/pubmed/32075913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011571
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