Manipulation of Cardiac Phosphatidylinositol 3-Kinase (PI3K)/Akt Signaling by Apoptosis Regulator through Modulating IAP Expression (ARIA) Regulates Cardiomyocyte Death during Doxorubicin-induced Cardiomyopathy

PI3K/Akt signaling plays an important role in the regulation of cardiomyocyte death machinery, which can cause stress-induced cardiac dysfunction. Here, we report that apoptosis regulator through modulating IAP expression (ARIA), a recently identified transmembrane protein, regulates the cardiac PI3...

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Main Authors: Kitamura, Youhei, Koide, Masahiro, Akakabe, Yoshiki, Matsuo, Kiyonari, Shimoda, Yoshiaki, Soma, Yuka, Ogata, Takehiro, Ueyama, Tomomi, Matoba, Satoaki, Yamada, Hiroyuki, Ikeda, Koji
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908411/
https://ncbi.nlm.nih.gov/pubmed/24338479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508143
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