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On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

Expansions of simple tandem repeats are responsible for almost 50 human diseases, the majority of which are severe, degenerative, and not currently treatable or preventable. In this review, we first describe the molecular mechanisms of repeat-induced toxicity, which is the connecting link between re...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Khristich, Alexandra N., Mirkin, Sergei M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105313/
https://ncbi.nlm.nih.gov/pubmed/32060097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.REV119.007678
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