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Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity
Ether-a-go-go (EAG) potassium selective channels are major regulators of neuronal excitability and cancer progression. EAG channels contain a Per–Arnt–Sim (PAS) domain in their intracellular N-terminal region. The PAS domain is structurally similar to the PAS domains in non-ion channel proteins, whe...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7105296/ https://ncbi.nlm.nih.gov/pubmed/32047112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012377 |
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