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Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity
Ether-a-go-go (EAG) potassium selective channels are major regulators of neuronal excitability and cancer progression. EAG channels contain a Per–Arnt–Sim (PAS) domain in their intracellular N-terminal region. The PAS domain is structurally similar to the PAS domains in non-ion channel proteins, whe...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7105296/ https://ncbi.nlm.nih.gov/pubmed/32047112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012377 |
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