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The Reduction Potentials of P450 Compounds I and II: Insight into the Thermodynamics of C-H Bond Activation.

We present a mixed experimental/theoretical determination of the bond strengths and redox potentials that define the ground state thermodynamics for C-H bond activation in cytochrome P450 catalysis. Using redox titrations with [Ir(IV)Cl(6)](2−) we have determined the compound II/ferric (or Fe(IV)OH/...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Mittra, Kaustuv, Green, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104868/
https://ncbi.nlm.nih.gov/pubmed/30892878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b00242
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