Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

The ubiquitous gasotransmitter hydrogen sulfide (H(2)S) has been recognized to play a crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient mice, we demonstrate an unexpected role of H(2)S in Mycobacterium tuberculosis (Mtb) pathogenesis. We showed that Mtb-infected CSE(−/−) mice...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Rahman, Md. Aejazur, Cumming, Bridgette M., Addicott, Kelvin W., Pacl, Hayden T., Russell, Shannon L., Nargan, Kievershen, Naidoo, Threnesan, Ramdial, Pratistadevi K., Adamson, John H., Wang, Rui, Steyn, Adrie J. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104411/
https://ncbi.nlm.nih.gov/pubmed/32139610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919211117
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