Effects of Hypoxia and Acidosis on Cardiac Electrophysiology and Hemodynamics. Is NHE-Inhibition by Cariporide Still Advantageous?

Hypoxia often leads to severe cardiac malfunctions. It is assumed that intracellular calcium overload is -inter alia- responsible for left ventricular (LV) deterioration. Inhibition of the sodium-proton exchanger (NHE), which finally inhibits/slows calcium overload, may ameliorate cardiac function....

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Dettagli Bibliografici
Pubblicato in:Front Physiol
Autori principali: Salameh, Aida, Zöbisch, Helena, Schröder, Bianca, Vigelahn, Jonas, Jahn, Mandy, Abraham, Getu, Seeger, Johannes, Dähnert, Ingo, Dhein, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103633/
https://ncbi.nlm.nih.gov/pubmed/32265732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00224
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