Effects of Hypoxia and Acidosis on Cardiac Electrophysiology and Hemodynamics. Is NHE-Inhibition by Cariporide Still Advantageous?

Hypoxia often leads to severe cardiac malfunctions. It is assumed that intracellular calcium overload is -inter alia- responsible for left ventricular (LV) deterioration. Inhibition of the sodium-proton exchanger (NHE), which finally inhibits/slows calcium overload, may ameliorate cardiac function....

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Main Authors: Aida Salameh, Helena Zöbisch, Bianca Schröder, Jonas Vigelahn, Mandy Jahn, Getu Abraham, Johannes Seeger, Ingo Dähnert, Stefan Dhein
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020-03-01
Sraith:Frontiers in Physiology
Ábhair:
cariporide
hypoxia
acidosis
electrophysiology
langendorff
Rochtain Ar Líne:https://www.frontiersin.org/article/10.3389/fphys.2020.00224/full
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