WDR5 is a conserved regulator of protein synthesis gene expression

WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the ‘WIN’ site) showing efficacy agains...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Bryan, Audra F, Wang, Jing, Howard, Gregory C, Guarnaccia, Alissa D, Woodley, Chase M, Aho, Erin R, Rellinger, Eric J, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Chung, Dai H, Fesik, Stephen W, Liu, Qi, Weissmiller, April M, Tansey, William P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102967/
https://ncbi.nlm.nih.gov/pubmed/31996893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa051
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