WDR5 is a conserved regulator of protein synthesis gene expression

WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the ‘WIN’ site) showing efficacy agains...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Bryan, Audra F, Wang, Jing, Howard, Gregory C, Guarnaccia, Alissa D, Woodley, Chase M, Aho, Erin R, Rellinger, Eric J, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Chung, Dai H, Fesik, Stephen W, Liu, Qi, Weissmiller, April M, Tansey, William P
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102967/
https://ncbi.nlm.nih.gov/pubmed/31996893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa051
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