WDR5 is a conserved regulator of protein synthesis gene expression

WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the ‘WIN’ site) showing efficacy agains...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Bryan, Audra F, Wang, Jing, Howard, Gregory C, Guarnaccia, Alissa D, Woodley, Chase M, Aho, Erin R, Rellinger, Eric J, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Chung, Dai H, Fesik, Stephen W, Liu, Qi, Weissmiller, April M, Tansey, William P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102967/
https://ncbi.nlm.nih.gov/pubmed/31996893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa051
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