GO: a functional reporter system to identify and enrich base editing activity

Base editing (BE) is a powerful tool for engineering single nucleotide variants (SNVs) and has been used to create targeted mutations in cell lines, organoids and animal models. Recent development of new BE enzymes has provided an extensive toolkit for genome modification; however, identifying and i...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Katti, Alyna, Foronda, Miguel, Zimmerman, Jill, Diaz, Bianca, Zafra, Maria Paz, Goswami, Sukanya, Dow, Lukas E
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Chemical Biology and Nucleic Acid Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102966/
https://ncbi.nlm.nih.gov/pubmed/32112097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa124
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