GO: a functional reporter system to identify and enrich base editing activity

Base editing (BE) is a powerful tool for engineering single nucleotide variants (SNVs) and has been used to create targeted mutations in cell lines, organoids and animal models. Recent development of new BE enzymes has provided an extensive toolkit for genome modification; however, identifying and i...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Katti, Alyna, Foronda, Miguel, Zimmerman, Jill, Diaz, Bianca, Zafra, Maria Paz, Goswami, Sukanya, Dow, Lukas E
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102966/
https://ncbi.nlm.nih.gov/pubmed/32112097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa124
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