Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium

The transcription factor Six1 is essential for induction of sensory cell fate and formation of auditory sensory epithelium, but how it activates gene expression programs to generate distinct cell-types remains unknown. Here, we perform genome-wide characterization of Six1 binding at different stages...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Li, Jun, Zhang, Ting, Ramakrishnan, Aarthi, Fritzsch, Bernd, Xu, Jinshu, Wong, Elaine Y M, Loh, Yong-Hwee Eddie, Ding, Jianqiang, Shen, Li, Xu, Pin-Xian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102962/
https://ncbi.nlm.nih.gov/pubmed/31956913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa012
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