Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA

Ubiquitylation of the eukaryotic sliding clamp, PCNA, activates a pathway of DNA damage bypass that facilitates the replication of damaged DNA. In its monoubiquitylated form, PCNA recruits a set of damage-tolerant DNA polymerases for translesion synthesis. Alternatively, modification by K63-linked p...

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Udgivet i:Nucleic Acids Res
Main Authors: Takahashi, Diane T, Wollscheid, Hans-Peter, Lowther, Jonathan, Ulrich, Helle D
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102961/
https://ncbi.nlm.nih.gov/pubmed/32009145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa053
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